Celiac Disease is Not a Food Allergy

Photo by Wesual Click on Unsplash

Misconceptions and Realities of Celiac Disease

If you’ve been diagnosed with Celiac disease for a while, you may have already noticed the widespread confusion about this condition among the general population unfamiliar with glute-free diets.

It also needs to be observed that an improvement in awareness over the last few years has been achieved.

Whenever I go our for dinner, especially in the past, a familiar scenario unfolds:

Me: “Are there any gluten-free options available on your menu?”

Waiter: “Unfortunately, we don’t have a specific gluten-free menu, but I’ll ensure that our kitchen excludes any milk or cheese from your dish!” (They often lack a gluten-free menu option and occasionally confuse gluten with lactose intolerance.)

Me: “Just to clarify, I’m fine with dairy; it’s gluten that I need to avoid.” The waiter’s expression hints at uncertainty about gluten. I then specify: “grains…wheat. I have Celiac disease”.

Waiter : ” Oh, got it. I’m sorry about that. I’ll make sure the kitchen knows about your allergy”.

I’m tempted to respond once more, saying ” Thanks, by the way, Celiac disease is not an allergy…”

However, I decided against it. It would be time-consuming to educate every waiter each time I go out.

For me, it’s satisfactory that they perceive it as an allergy, even if it’s not accurate, Sometimes, it works to my advantage. At least they will take extra precautions to prevent cross-contact in order to safeguard against a potential severe ‘allergic’ reaction.

The reality is that not many people are familiar with Celiac disease, and I, too, had limited knowledge when I first learned about my condition. The initial realization meant giving up some of my favorite foods like bread, pizza, and pasta. That much was clear. However, I soon discovered that there’s much more to Celiac disease than just dietary restrictions.

Let’s begin with some basic information.

Gluten consists of two types of proteins, namely gliding, and glutenin, which are found in wheat, barley, and rye.

Gliadin, a component of the gluten protein, is considered the primary environmental trigger responsible for celiac disease.

Celiac disease is an autoimmune disease (not an allergy), that might manifest in individuals with a genetic predisposition, meaning that every time gluten is ingested, even a small amount, the immune system mistakenly sees the gluten as a foreign invader and reacts by attacking the small intestine, impeding the absorption of nutrients from food and leading to malabsorption syndrome.

To potentially develop Celiac disease, one must carry one of the two genes associated with the condition: HLA-DQ2 or HLA-DQ8. However, having HLA-DQ2 and/or DQ8 does not guarantee the development of celiac disease; it simply increases the risk compared to the rest of the population without these genes. Many individuals with celiac disease do possess at least one of these genes. In exceptionally rare cases, a person may not have these genes but could still develop celiac disease.

The suggested safe amount of gluten for individuals with celiac disease is 20 parts per million (ppm), which translates to 20 milligrams of gluten per 1 kilogram of food. This level is intended to keep most people below the 10 mg threshold, although there isn’t a clear consensus on the safe daily intake of gluten. Individual tolerance varies, with some people being more tolerant than others, and vice versa.

Understanding the fundamental distinction between an allergy and an autoimmune disease is crucial. In the case of an allergy . depending on its severity , it could lead to anaphylactic shock, which is life-threatening and may prove fatal without prompt intervention.

However, with Celiac disease, being an autoimmune condition, such a scenario is impossible unless there is an additional wheat allergy alongside Celiac disease.

People with Celiac disease do not get anaphylaxis when they eat gluten.

Symptoms of food allergies typically manifest quickly, whereas, in Celiac disease, a delayed hypersensitivity reaction occurs. Symptoms usually develop within 48–72 hours after the ingestion of the offending food, which, in this case, is gluten. Some may react within 2–3 hours with severe vomiting and/or diarrhea.

Common symptoms for individuals with Celiac disease following gluten ingestion can include:

  1. Nausea
  2. Vomiting
  3. Gas/bloating
  4. Cramps
  5. Abdominal pain
  6. Diarrhea
  7. Constipation
  8. Tiredness

While common symptoms of a food allergy can include:

  1. Feeling dizzy or lightheaded.
  2. Itchy skin or a raised rash (hives)
  3. Swelling of the lips, face and eyes
  4. Coughing, wheezing, breathlessness
  5. Sneezing or an itchy, runny or blocked nose
  6. Feeling sick or being sick
  7. Stomach cramps

Anaphylaxis ( this is a severe allergic reaction- although the condition is life threatening, deaths are rare )

Allergies are triggered by a different type of antibody known as IgE(immunoglobulin E antibodies).

Conversely, Celiac disease is triggered by IgA antibodies, specifically Tissue Transglutaminase IgA antibody or tTG-IgA. This antibody targets an enzyme present in the lining of the gastrointestinal tract and correlates with the degree of mucosal damage in individuals with Celiac disease.

As of now, the only known therapy to manage Celiac disease is to follow a strict, lifelong gluten-free diet.

I hope this helps clarify the distinction between autoimmune diseases and allergies, specifically highlighting the difference between a food allergy and Celiac disease.  

Originally published on Medium© 2024 Iose Cocuzza. All rights reserved.

Medical Disclaimer: I am not a medical doctor. The information presented in this article is not intended to offer medical advice but is provided for informational purposes only. It should not be seen as a replacement for professional medical advice or consultation with healthcare professionals.


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References:

Celiac disease

Celiac disease differs from IgE-mediated food allergies in several important respects. Celiac disease is NOT mediated…

farrp.unl.edu

IgE-Dependent Allergy in Patients with Celiac Disease: A Systematic Review

In order to answer the question if an IgE-mediated allergy (A-IgE) may occur in subjects with celiac disease (CD), a…

www.ncbi.nlm.nih.gov

Beyond the HLA Genes in Gluten-Related Disorders

Most common food grains contain gluten proteins and can cause adverse medical conditions generally known as…

www.ncbi.nlm.nih.gov

How Genetics Play a Role in Your Risk of Celiac Disease

The gene known as HLA-DQ8 is one of two main celiac disease genes, known to increase the risk of gluten intolerance as…

www.verywellhealth.com

Gluten in Celiac Disease-More or Less?

To date, the only known effective treatment for celiac disease is a strict gluten-free diet for life. We reviewed the…

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